Primus systems combine the best in accuracy and precision resulting in the most clinically useful test for A1c available.

Precision

Primus A1c methods use automated HPLC technology recognized for superior precision. A procedure may be very reproducible but have limitations in its chemistry, where it is predictably not accurate. Variations in the nature of the sample give such predicted loss of accuracy.

Accuracy

Primus A1c methods are the most accurate methods available. A method may give accurate result, on the average, meaning that the method is correctly designed, with the right chemistry theory, but the procedure has variables in it like time of reaction (elution) strength of reagents, etc. that are not always the same. Primus methods use boronate affinity technology known for its superior accuracy.

Patient Conditions where a result may be precise, but not accurate:

Condition	Methodology susceptible to inaccuracy due to patient condition
Splenectomy 1	Ion Exchange, Immunochemistry or Boronate Affinity methods
Gallactosemia 2	Ion Exchange, Immunochemistry or Boronate Affinity methods
Uremia 3	Ion Exchange, Immunochemistry or Boronate Affinity methods
Anemia 4	Ion Exchange, Immunochemistry or Boronate Affinity methods
Thalassemia	Ion Exchange or Immunochemistry ONLY
Hb F	Ion Exchange or Immunochemistry ONLY
Other Variants	Ion Exchange or Immunochemistry ONLY

*All of these patients require special interpretation

 

Some patient hemoglobins cause difficulty of interpretation in all methods, and some only with ion exchange (charge related) or immunochemistry methods.

1. In splenectomy, RBC are not destroyed and continue to accumulate GHb or A1c.
2. In galactosemia, another sugar accumulates on all hemoglobin.
3. In uremia, the groups that could have sugar attached are used up by another chemical group.
4. In anemia, the red blood cell turnover is too fast and A1c or GHb never develops.